Ganglioneuroblastoma Vs Neuroblastoma
Neuroblastoma, ganglioneuroblastoma and ganglioneuroma are neoplasms that arise from either dorsal root ganglion of spinal cord or medulla of adrenal gland. Neuroblastoma (NB) is predominantly composed of neuroblasts with small round nuclei and stippled chromatin (salt and pepper). They may have prominent nucleoli and nuclei are 1.5 -2x larger. They are usually schwannian stroma poor which means have <50% schwannian stroma (it may be absent altogether). On the other hand, ganglioneuroblastomas (GNB) are rich in ganglion cells which have nissls substance in its cytoplasm and are schwannian stroma rich (>50%).